No, I haven't seen everything in Italy (nobody has, or ever can), and this is one of my big gaps. The town of Lecce (LEH-cheh) is a major attraction in Southern Italy, with spectacular architecture, food and wine. In fact the entire Salento area of Puglia (the heel of the boot) is worthy of consideration, and might well be the focus of your next vacation.
Here is today's New York Times article on the lovely city.